Hydrochloric Acid → HCID 14751603, compound

HRID 1646872Notes

Reaction equation

HRID 1646872 reaction equation
[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[O:4][C:3]1=[O:11].[Cl:12][CH2:13][CH2:14][C:15](Cl)=[O:16].Cl>>[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][C:9]([C:15](=[O:16])[CH2:14][CH2:13][Cl:12])=[CH:10][C:5]=2[O:4][C:3]1=[O:11]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 308462-Benzoxazolinone, 3-methyl-HCID 693643-Chloropropionyl chloride

Product 1

HCID 14751603HCID 14751603, compound

Conditions

Temperature
75 °C

Procedure

The flask is equipped with a reflux condenser and taken to an oil bath at a temperature in the region of 40°-45° C. 0.04 mole of 3-methylbenzoxazolinone and 0.44 mole of 3-chloropropionic acid chloride are introduced. The mixture is heated to a temperature in the region of 75° C. for 2 hours 30 minutes. After cooling, the reaction mixture is poured into 300 g of ice, acidified with concentrated hydrochloric acid and stirred for hour 30 minutes. The precipitate obtained is drained, washed with water and dried. The product is recrystallized in ethanol.

Workup

  1. customThe flask is equipped with a reflux condenser
  2. customtaken to an oil bath at a temperature in the region of 40°-45° C
  3. temperatureAfter cooling
  4. customThe precipitate obtained
  5. washwashed with water
  6. customdried
  7. customThe product is recrystallized in ethanol

Sources & evidence

ORD record
ord-8621da19544e4ca89fed8b5f772950aa
Source dataset
uspto-grants-1993_01
Patent number
US05182278

Reaction notes

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