1-Bromo-3-chloropropane → HCID 14880470, compound

HRID 1646945Notes

Reaction equation

HRID 1646945 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]([C:10]1[CH:18]=[CH:17][CH:16]=[C:15]2[C:11]=1[CH:12]=[CH:13][NH:14]2)=[O:9].Br[CH2:20][CH2:21][CH2:22][Cl:23]>>[Cl:23][CH2:22][CH2:21][CH2:20][O:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]([C:10]1[CH:18]=[CH:17][CH:16]=[C:15]2[C:11]=1[CH:12]=[CH:13][NH:14]2)=[O:9]

Participants

3

Reactant 2

HCID 80061-Bromo-3-chloropropaneHCID 14880469HCID 14880469, compound

Product 1

HCID 14880470HCID 14880470, compound

Procedure

Using the procedure of Step E of Example 1, 10,9 g of the product of Step D and 18.17 ml of 1-bromo-3-chloro propane were reacted to obtain after chromatography on silica (eluant: methylene chloride - hexane (75-25]), 14.4 g of the desired product melting at 94° C., which was used as is for the following step.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-6bf8183dc2be41c5bf356610968d5b62
Source dataset
uspto-grants-1993_01
Patent number
US05182282

Reaction notes

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