Water → HCID 14995660, compound

HRID 1646963Notes

Reaction equation

HRID 1646963 reaction equation
C(=O)([O-])[O-].[K+].[K+].[Br:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[OH:14].[CH3:15][O:16][C:17]1[CH:22]=[CH:21][C:20]([C:23](=[O:26])[CH2:24]Br)=[CH:19][CH:18]=1.O>CC(C)=O>[Br:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[O:14][CH2:24][C:23]([C:20]1[CH:21]=[CH:22][C:17]([O:16][CH3:15])=[CH:18][CH:19]=1)=[O:26]

Participants

6

Reactant 4

HCID 962WaterHCID 4965Bromomethyl 4-methoxyphenyl ketoneHCID 72442-BromophenolHCID 11430Potassium Carbonate

Product 1

HCID 14995660HCID 14995660, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent2×

Procedure

44.3 g of potassium carbonate were added to a mixture of 34 ml of 2-bromo phenol, 150 ml of acetone and 75 g of 4'-methoxy-2-bromo acetophenone in 150 ml of acetone. The mixture was refluxed for 16 hours and the solution was poured into water. The aqueous phase was extracted with ethyl acetate, dried, filtered and brought to dryness to obtain 101 g of the desired product melting at 104° C.

Workup

  1. temperatureThe mixture was refluxed for 16 hours
  2. extractionThe aqueous phase was extracted with ethyl acetate
  3. customdried
  4. filtrationfiltered

Sources & evidence

ORD record
ord-920d73ef86c946df93a960cbe7fa3061
Source dataset
uspto-grants-1993_01
Patent number
US05182295

Reaction notes

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