Methanol → HCID 67875982, compound

HRID 1646967Notes

Reaction equation

HRID 1646967 reaction equation
[C-:1]#[N:2].[K+].BrC[C:6]1[C:14]2[O:13][C:12]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)=[CH:11][C:10]=2[CH:9]=[CH:8][CH:7]=1.[CH3:21]O>>[C:15]1([C:12]2([CH2:21][C:1]#[N:2])[CH2:11][CH:10]=[C:9]3[CH:8]=[CH:7][CH:6]=[C:14]3[O:13]2)[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

Participants

4

Reactant 3

HCID 887Methanol2×HCID 9032Potassium CyanideHCID 19800323HCID 19800323, compound

Product 1

HCID 67875982HCID 67875982, compound

Procedure

11 g of potassium cyanide were added to 110 ml of methanol and then 23.5 g of 7-(bromomethyl)-2-phenyl benzofuran (Helvetica Chimica Acta, Vol. 57, 5, 1974, p. 1381) in 250 ml of methanol were added. The mixture was refluxed for 5 hours, then separated, filtered and concentrated. The crystals were crystallized from flugene-1,1,3 at reflux to obtain 5.78 g of the desired product melting at 65° C.

Workup

  1. temperatureThe mixture was refluxed for 5 hours
  2. customseparated
  3. filtrationfiltered
  4. concentrationconcentrated
  5. customThe crystals were crystallized from flugene-1,1,3
  6. temperatureat reflux

Sources & evidence

ORD record
ord-2b7aeb08a9c842089f3e5782bb8cdfac
Source dataset
uspto-grants-1993_01
Patent number
US05182295

Reaction notes

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