2-Chloroquinoxaline → 2-Fluoroquinoxaline

HRID 1647012Notes

Reaction equation

HRID 1647012 reaction equation
Cl[C:2]1[CH:11]=[N:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[F-:12].[K+]>CS(C)=O>[F:12][C:2]1[CH:11]=[N:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

Participants

4

Reactant 2

HCID 2389382-ChloroquinoxalineHCID 522689Potassium Fluoride

Product 1

HCID 109425992-Fluoroquinoxaline

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

A mixture of 2-chloroquinoxaline (1.65 g, 10 mmol), potassium fluoride (1.16 g, 20 mmol) and dry dimethyl sulfoxide (10 mL) was heated with stirring for 4 h. After cooling to room temperature the mixture was filtered through silica gel with 10% ether/hexane as the eluent to afford 2-fluoroquinoxaline as a colorless oil.

Workup

  1. temperaturewas heated
  2. filtrationwas filtered through silica gel with 10% ether/hexane as the eluent

Sources & evidence

ORD record
ord-5fdda6dfe6e64a8584a5ca98d05afa78
Source dataset
uspto-grants-1993_01
Patent number
US05182386

Reaction notes

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