HCID 67884316, compound → HCID 15680279, compound

HRID 1647025Notes

Reaction equation

HRID 1647025 reaction equation
[CH2:1]1[O:9][C:8]2[C:3]3([O:18][CH2:17][O:16][C:15]4[CH:14]=[CH:13][CH:12]=[C:11]([C:19]([NH2:21])=O)[C:10]=4[C:7]=2[C:6]([C:22]([NH2:24])=O)=[CH:5][CH2:4]3)[O:2]1>P(Cl)(Cl)(Cl)=O>[CH2:1]1[O:9][C:8]2[C:3](=[CH:4][CH:5]=[C:6]([C:22]#[N:24])[C:7]=2[C:10]2[C:11]([C:19]#[N:21])=[CH:12][CH:13]=[C:14]3[O:18][CH2:17][O:16][C:15]=23)[O:2]1

Participants

3

Reactant 1

HCID 67884316HCID 67884316, compound

Product 1

HCID 15680279HCID 15680279, compoundYield 91.8%

Reagents, catalysts & solvents 1

HCID 24813Phosphorus oxychlorideSolvent

Procedure

5,6-Methylenedioxy-5,6' -methylenedioxy-2,2'-biphenyldicarboxamide (8 g) is refluxed in phosphorus oxychloride (70 ml) for 4 hours. The reaction mixture is cooled and then poured into ice water. The precipitated crystals are separated by filtration and dissolved in chloroform. The solution is washed with water, dried and distilled to remove the solvent to give 5,6-methylenedioxy-5',6'-methylenedioxy-2,2'-biphenyldicarbonitrile (6.5 g) as colorless crystal. M.p. 213°-215° C.

Workup

  1. temperatureThe reaction mixture is cooled
  2. customThe precipitated crystals are separated by filtration
  3. dissolutiondissolved in chloroform
  4. washThe solution is washed with water
  5. customdried
  6. distillationdistilled
  7. customto remove the solvent

Sources & evidence

ORD record
ord-b8a191d1e2124d4dbf24872734b790a0
Source dataset
uspto-grants-1993_01
Patent number
US05182404

Reaction notes

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