Methyl Acrylate → HCID 86748755, compound

Participants

Reaction Steps

A mixture of 5.1 g of 6-methyl-8β-aminomethyl-13-t-butyl-ergoline and 1.8 ml methyl acrylate in 100 ml of methanol was refluxed for 4 hours. The solvent was evaporated off and the residue was crystallized from ethylacetate to afford 6 g of 6-methyl-8β-N-(2-methoxycarbonylethyl)aminomethyl-13-t-butyl-ergoline, melting at 153°-157° C., (I, R1 =R2 =H, R3 =CH3, A=NHC2H4CO2CH3, n=1).

Provenance & Evidence