Methyl Acrylate → HCID 86748755, compound

HRID 1647085Notes

Reaction equation

HRID 1647085 reaction equation
[CH3:1][N:2]1[C@H:16]2[C@@H:6]([C:7]3[CH:8]=[C:9]([C:18]([CH3:21])([CH3:20])[CH3:19])[CH:10]=[C:11]4[C:17]=3[C:14]([CH2:15]2)=[CH:13][NH:12]4)[CH2:5][C@@H:4]([CH2:22][NH2:23])[CH2:3]1.[C:24]([O:28][CH3:29])(=[O:27])[CH:25]=[CH2:26]>CO>[CH3:1][N:2]1[C@H:16]2[C@@H:6]([C:7]3[CH:8]=[C:9]([C:18]([CH3:19])([CH3:20])[CH3:21])[CH:10]=[C:11]4[C:17]=3[C:14]([CH2:15]2)=[CH:13][NH:12]4)[CH2:5][C@@H:4]([CH2:22][NH:23][CH2:26][CH2:25][C:24]([O:28][CH3:29])=[O:27])[CH2:3]1

Participants

4

Reactant 2

HCID 7294Methyl AcrylateHCID 10519127HCID 10519127, compound

Product 1

HCID 86748755HCID 86748755, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 5.1 g of 6-methyl-8β-aminomethyl-13-t-butyl-ergoline and 1.8 ml methyl acrylate in 100 ml of methanol was refluxed for 4 hours. The solvent was evaporated off and the residue was crystallized from ethylacetate to afford 6 g of 6-methyl-8β-N-(2-methoxycarbonylethyl)aminomethyl-13-t-butyl-ergoline, melting at 153°-157° C., (I, R1 =R2 =H, R3 =CH3, A=NHC2H4CO2CH3, n=1).

Workup

  1. temperaturewas refluxed for 4 hours
  2. customThe solvent was evaporated off
  3. customthe residue was crystallized from ethylacetate

Sources & evidence

ORD record
ord-ae8b25831aa64bf990ec48b815b1e718
Source dataset
uspto-grants-1995_07
Patent number
US05430031

Reaction notes

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