反应详情

To a solution of N-(tert-butoxycarbonyl)-L-valine (10.86 g) and L-proline benzyl ester hydrochloride (12.09 g) in DMF (50 ml) were added HOBT (6.76 g) and WSCD (7.76 g) under ice-bath cooling. After being stirred at room temperature for 18 hours, the reaction mixture was concentrated under reduced pressure. The residue was dissolved in ethyl acetate (400 ml) and washed with 5% aqueous citric acid (200 ml) saturated aqueous sodium bicarbonate (200 ml). The solution was dried over magnesium sulfate and evaporated under reduced pressure to give N-(tert-butoxycarbonyl)-L-valyl-L-proline benzyl ester (20.06 g) as an oil.

1. temperaturecooling
2. concentrationthe reaction mixture was concentrated under reduced pressure
3. dissolutionThe residue was dissolved in ethyl acetate (400 ml)
4. washwashed with 5% aqueous citric acid (200 ml) saturated aqueous sodium bicarbonate (200 ml)
5. dry with materialThe solution was dried over magnesium sulfate
6. customevaporated under reduced pressure