反应详情

To a solution of 3-methoxybenzylalcohol (50.0 g, 0.36 mol) in ether (1.1 L) at -20° C. was added n-BuLi (76.0 mL, 0.756 mol) at such a rate that the internal temperature of the reaction was maintained at less than -10° C. When the addition of n-BuLi was complete, the mixture was warmed to room temperature and stirred for 2 hours. The mixture was cooled to 0° C. and tetramethylethylene diamine (42.0 g, 0.36 mol) was added. The reaction mixture was cooled to -30° C. and 2-pyridinecarboxaldehyde (58.0 g, 0.36 mol) was added over 5 minutes. The reaction was warmed to 0° C. over a 30 minute period and was then quenched with water (500 mL). The mixture was chilled for 24 hours, and the product was collected by filtration and washed with ether. The product was recrystallized from ethanol to afford 30.0 g (34%) of α-[2-(hydroxymethyl)-6-methoxyphenyl]-2-pyridinemethanol (Formula X: R2 =6-OCH3 ; R1 =H). The mother liquor from the recrystallization step was concentrated, diluted with ether and refrigerated for 16 hours. A solid precipitated, which was collected by filtration to afford an additional 13.1 g of the desired product for a total of 43.1 g (49%).

1. temperaturewas maintained at less than -10° C
2. temperatureThe mixture was cooled to 0° C.
3. temperatureThe reaction mixture was cooled to -30° C.
4. temperatureThe reaction was warmed to 0° C. over a 30 minute period
5. customwas then quenched with water (500 mL)
6. temperatureThe mixture was chilled for 24 hours
7. filtrationthe product was collected by filtration
8. washwashed with ether
9. customThe product was recrystallized from ethanol