Trifluoroacetic acid → HCID 67798894, compound

HRID 1647102Notes

Reaction equation

I.C([O:6][C:7](=[O:46])[C@H:8]([CH2:39][C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1)[NH:9][C:10](=[O:38])[C@H:11]([CH2:30][C:31]([O:33]C(C)(C)C)=[O:32])[NH:12][C:13](=[O:29])[CH2:14][C:15](=[O:28])[NH:16][CH2:17][CH2:18][C:19]1[CH:24]=[CH:23][C:22]([C:25](=[NH:27])[NH2:26])=[CH:21][CH:20]=1)(C)(C)C.[F:47][C:48]([F:53])([F:52])[C:49]([OH:51])=[O:50]>>[F:47][C:48]([F:53])([F:52])[C:49]([OH:51])=[O:50].[C:25]([C:22]1[CH:23]=[CH:24][C:19]([CH2:18][CH2:17][NH:16][C:15]([CH2:14][C:13]([NH:12][C@H:11]([C:10]([NH:9][C@H:8]([C:7]([OH:46])=[O:6])[CH2:39][C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=2)=[O:38])[CH2:30][C:31](=[O:32])[OH:33])=[O:29])=[O:28])=[CH:20][CH:21]=1)(=[NH:26])[NH2:27]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 67797187HCID 67797187, compound

Product 1

HCID 67798894HCID 67798894, compound

Procedure

100 mg of N-[N-[(p-amidinophenethyl-carbamoyl)acetyl]-3-(t-butoxycarbonyl)-L-alanyl]-3-phenyl-L-alanine t-butyl ester hydroiodide were reacted with trifluoroacetic acid as described in Example 1 to give 69 mg of N-[N-[(p-amidinophenethylcarbamoyl)acetyl]-L-α-aspartyl]-3-phenyl-L-alanine trifluoroacetate, m.p. 141°-143° C., after crystal-lisation using diethyl ether.

Sources & evidence

ORD record: ord-f8f8d65ece514b05873367aff51cd2b8
Source dataset: uspto-grants-1995_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05430024

Reaction notes

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