Chlorotrimethylsilane → Leucyl-leucine-methyl ester

HRID 1647341Notes

Reaction equation

HRID 1647341 reaction equation
[NH2:1][C@H:2]([C:7]([OH:9])=[O:8])[CH2:3][CH:4]([CH3:6])[CH3:5].[NH2:10][C@H:11]([C:16]([OH:18])=O)[CH2:12][CH:13]([CH3:15])[CH3:14].[CH3:19][Si](Cl)(C)C>CO>[CH3:19][O:8][C:7](=[O:9])[C@H:2]([CH2:3][CH:4]([CH3:6])[CH3:5])[NH:1][C:16](=[O:18])[C@H:11]([CH2:12][CH:13]([CH3:15])[CH3:14])[NH2:10]

Participants

4

Reactant 2

HCID 6397ChlorotrimethylsilaneHCID 22842050L-leucine L-leucine

Product 1

HCID 7016877Leucyl-leucine-methyl ester

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To 0.50 g of L-leucine-L-leucine, under argon, is added, via a syringe, 10 ml of methyl alcohol and 0.610 ml of trimethylsilyl chloride. The reaction is stirred overnight at room temperature. The mixture is concentrated in vacuo to give 0.554 g of the desired product.

Workup

  1. concentrationThe mixture is concentrated in vacuo

Sources & evidence

ORD record
ord-ff76d6afcc7f43d2a52e1c24cc33943a
Source dataset
uspto-grants-1995_07
Patent number
US05430150

Reaction notes

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