HCID 41473673, compound → 1H-Benzimidazole-2-methanamine,alpha-methyl-,(R)-(9CI)

HRID 1647347Notes

Reaction equation

HRID 1647347 reaction equation
C1(COC(=O)[NH:10][C@@H:11]([C:13]2[NH:17][C:16]3[CH:18]=[CH:19][CH:20]=[CH:21][C:15]=3[N:14]=2)[CH3:12])C=CC=CC=1>[Pd].CO>[CH3:12][C@H:11]([C:13]1[NH:14][C:15]2[CH:21]=[CH:20][CH:19]=[CH:18][C:16]=2[N:17]=1)[NH2:10]

Participants

4

Reactant 1

HCID 41473673HCID 41473673, compound

Product 1

HCID 6932331H-Benzimidazole-2-methanamine,alpha-methyl-,(R)-(9CI)Yield 82.2%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

The title compound is prepared by the procedure of Example 15, in a Parr apparatus, using 1.07 g of product from Example 44, 90 ml of methyl alcohol and 2.45 g of 10% palladium on carbon to give 0.48 g of the desired product after recrystallization from carbon tetrachloride.

Workup

  1. customThe title compound is prepared by the procedure of Example 15, in a Parr apparatus

Sources & evidence

ORD record
ord-b4e99cbdce28429d8e125314d9669e96
Source dataset
uspto-grants-1995_07
Patent number
US05430150

Reaction notes

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