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HRID1647375

反应详情

EQUATION

反应方程式

HRID 1647375 的结构方程式

REACTANTS

反应物

2
结构：CC(=O)OC(C)=O
HCID7918

Acetic anhydride

C4H6O3

结构：Nc1ccccc1B(O)O
HCID2773216

2-Aminophenylboronic acid

C6H8BNO2

PRODUCTS

生成物

1
结构：CC(=O)Nc1ccccc1B(O)O
HCID2737789

2-Acetamidophenylboronic acid

C8H10BNO3

收率 83.4%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1COCCO1
溶剂HCID31275

1,4-Dioxane

C4H8O2

CONDITIONS

反应条件

温度
100 °C

PROCEDURE

实验过程

To a solution of o-aminophenylboronic acid (6.73 g, 49.1 mmoles) in dioxane (100 ml) is added acetic anhydride (25.1 g, 246 mmoles). The reaction is heated at 100° C. for 17 hours. After cooling, the reaction volatiles are removed under reduced pressure to leave a thick yellow gel, which after chromatography affords o-N-acetylaminophenylboronic acid (7.33 g).

WORKUP

后处理

  1. temperatureAfter cooling
  2. customthe reaction volatiles
  3. customare removed under reduced pressure
  4. customto leave a thick yellow gel, which after chromatography