HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1647375Generated: October 30, 2026
Acetic Anhydride → 2-Acetamidophenylboronic acid
https://huagongshe.com/reaction/1647375
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | (2-Aminophenyl)boronic acid | HCID 2773216 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2-Acetamidophenylboronic acid | HCID 2737789 | 83.4% |
Reaction Steps
To a solution of o-aminophenylboronic acid (6.73 g, 49.1 mmoles) in dioxane (100 ml) is added acetic anhydride (25.1 g, 246 mmoles). The reaction is heated at 100° C. for 17 hours. After cooling, the reaction volatiles are removed under reduced pressure to leave a thick yellow gel, which after chromatography affords o-N-acetylaminophenylboronic acid (7.33 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05431842 |
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| Source dataset | uspto-grants-1995_07 |
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| ORD ID | ord-dfa39f9d19974ea6bb4af0b0a8ab1370 |
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| Source note | uspto-grants-1995_07 |
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