反应详情

Ethyl 2-butyryl-3-(2-(4-methoxybenzoyloxymethyl)-phenylamino)acrylate (12.2 g, 28.7 mmol) was added in portions to boiling diphenyl ether (200 ml), then heated at reflux for 30 minutes. Most of the diphenyl ether was distilled off in vacuo, and the residue triturated with ether to give 3-butyryl-8-(4-methoxybenzoyloxymethyl)-4(1H)-quinolone (5.85 g, 54%), m.p. 156°-162°.

1. temperatureheated
2. temperatureat reflux for 30 minutes
3. distillationMost of the diphenyl ether was distilled off in vacuo
4. customthe residue triturated with ether