反应详情

A solution of 3-butyryl-8-(4-methoxybenzoyloxymethyl)-4(1H)-quinolone (5.75 g, 15.1 mmol) in phosphoryl chloride (75 ml) was heated at reflux for 30 minutes, the phosphoryl chloride evaporated in vacuo, the residue poured onto ice, neutralised with sodium bicarbonate, and extracted into dichloromethane. Drying, evaporation, and trituration with ether gave the crude 3-butyryl-4-chloro-8-(4-methoxy-benzoyloxymethyl)quinoline, which was used without further purification.

1. temperatureat reflux for 30 minutes
2. customthe phosphoryl chloride evaporated in vacuo
3. additionthe residue poured onto ice
4. extractionextracted into dichloromethane
5. customDrying
6. customevaporation, and trituration with ether