Boron tribromide → HCID 10377396, compound

HRID 1647442Notes

Reaction equation

HRID 1647442 reaction equation
[C:1]([C:6]1[CH:7]=[N:8][C:9]2[C:14]([C:15]=1[Cl:16])=[CH:13][CH:12]=[CH:11][C:10]=2[O:17]C)(=[O:5])[CH2:2][CH2:3][CH3:4].B(Br)(Br)Br>ClCCl>[C:1]([C:6]1[CH:7]=[N:8][C:9]2[C:14]([C:15]=1[Cl:16])=[CH:13][CH:12]=[CH:11][C:10]=2[OH:17])(=[O:5])[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 25134Boron tribromideHCID 117775673-Butyryl-4-chloro-8-methoxyquinoline

Product 1

HCID 10377396HCID 10377396, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3-Butyryl-4-chloro-8-methoxyquinoline (26.3 g, 0.1 mol) in dichloromethane (250 ml) was cooled to -78° under nitrogen, and boron tribromide (75 g, 0.3 mol) added slowly. The solution was stirred overnight, warming gradually to room temperature, then quenched with water. The organic solution was separated and evaporated to give the crude product, which was used immediately without further purification.

Workup

  1. customquenched with water
  2. customThe organic solution was separated
  3. customevaporated

Sources & evidence

ORD record
ord-2d12f54b6efe48b59c81b75ad2ae09ac
Source dataset
uspto-grants-1995_07
Patent number
US05432182

Reaction notes

Loading…