HCID 178450497, compound → HCID 10405519, compound

HRID 1647450Notes

Reaction equation

HRID 1647450 reaction equation
C([O:3][C:4](=O)[C:5]([C:24](=[O:28])[CH2:25][CH2:26][CH3:27])=[CH:6][NH:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][O:15][C:16](=[O:23])[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[CH:10][CH:9]=1)C>C1(OC2C=CC=CC=2)C=CC=CC=1>[C:24]([C:5]1[C:4](=[O:3])[C:9]2[C:8](=[CH:13][CH:12]=[C:11]([CH2:14][O:15][C:16](=[O:23])[C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)[CH:10]=2)[NH:7][CH:6]=1)(=[O:28])[CH2:25][CH2:26][CH3:27]

Participants

3

Reactant 1

HCID 178450497HCID 178450497, compound

Product 1

HCID 10405519HCID 10405519, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 7583Diphenyl EtherSolvent

Procedure

Ethyl-2-butyryl-3-(4-benzoyloxymethylphenylamino)acrylate (50 g) was added portionwise to boiling diphenyl ether (500 ml) and hearing continued under reflux for 30 minutes. On cooling, crystals started to appear and the mixture was diluted with petroleum ether to give 3-butyryl-6-(benzoyloxymethyl)-4(1H)-quinolone (39.7 g, 96%) as light brown crystals, m.p. 220°-3° C.

Workup

  1. temperatureunder reflux for 30 minutes
  2. temperatureOn cooling

Sources & evidence

ORD record
ord-0deb78a095a5400c94398b2cc55c6075
Source dataset
uspto-grants-1995_07
Patent number
US05432182

Reaction notes

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