Phosphorus oxychloride → HCID 10338985, compound

Participants

Reaction Steps

3-Butyryl-7-benzoyloxymethyl-4(1H)-quinolone (10.42 g, 29.8 mmol) and phosphoryl chloride (60 ml) were refluxed for 1 hour, then evaporated, and the residue poured onto ice (300 g) with stirring. After neutralising with concentrated ammonia, the product was extracted into chloroform and the solution dried (Na2SO4) and evaporated to a solid. Trituration with ether gave the title compound (9.76 g), m.p. 66°-8°.

Provenance & Evidence