反应详情

3-Butyryl-7-benzoyloxymethyl-4(1H)-quinolone (10.42 g, 29.8 mmol) and phosphoryl chloride (60 ml) were refluxed for 1 hour, then evaporated, and the residue poured onto ice (300 g) with stirring. After neutralising with concentrated ammonia, the product was extracted into chloroform and the solution dried (Na2SO4) and evaporated to a solid. Trituration with ether gave the title compound (9.76 g), m.p. 66°-8°.

1. customevaporated
2. additionthe residue poured onto ice (300 g)
3. extractionthe product was extracted into chloroform
4. dry with materialthe solution dried (Na2SO4)
5. customevaporated to a solid