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HRID1647496

反应详情

EQUATION

反应方程式

HRID 1647496 的结构方程式

REACTANTS

反应物

2
结构：C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO
HCID9782

Betamethasone

C22H29FO5

结构：C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COP(=O)([O-])[O-].[Na+].[Na+]
HCID65478

Betamethasone 21-phosphate disodium

C22H28FNa2O8P

PRODUCTS

生成物

1
结构：C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2C(=O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO
HCID222786

Cortisone

C21H28O5

PROCEDURE

实验过程

Eight rabbits of the New Zealand breed were used, weighing approximately 2 kg. In the right eye of each animal, 0.8 ml/week of Bentelan Depot (equivalent to 4 mg betametasone) were instilled for 4 weeks. The left eye was kept as control. The medicament, administered subconjunctivally, brought about an increase of the intraocular tension in the first week, reached its peak in the second week and then remained constant until the fifth week.

WORKUP

后处理

  1. temperaturean increase of the intraocular tension in the first week
  2. customremained constant until the fifth week