HRID1647608

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID3283

Diethyl Ether

C4H10O

HCID137980

Thiazole, 5-methyl-

C4H5NS

结构：CCCCCCCCCCCCCCOc1ccc(CCNC(=O)Cc2cccc(CBr)c2)cc1

HCID86745366

未命名化合物

PRODUCTS

生成物

结构：CCCCCCCCCCCCCCOc1ccc(CCN(C(C)=O)c2cccc(C[n+]3csc(C)c3)c2)cc1.[Br-]

HCID10416740

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID1140

Toluene

C7H8

PROCEDURE

实验过程

A mixture of 2.5 g N-[3-(bromomethyl)phenyl-N-[2-[4-(tetradecyloxy)phenyl]ethyl]acetamide and 2.28 g of 5-methylthiazole in 50 ml of toluene is refluxed for 5 hours, cooled and ether added. The solid is collected by centrifugation and washed several times with ether then vacuum dried to give 1.8 g of the desired product as a white solid, m.p. 136°-140° C.

WORKUP

后处理

temperatureis refluxed for 5 hours
temperaturecooled
customThe solid is collected by centrifugation
washwashed several times with ether
customvacuum dried

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4ef50914e0ea4736a231dc7fd39736c7
来源数据集: uspto-grants-1995_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05432189
来源说明: uspto-grants-1995_07

反应 SMILES

[Br:1]CC1[CH:4]=[C:5]([CH2:9][C:10]([NH:12][CH2:13][CH2:14][C:15]2[CH:20]=[CH:19][C:18]([O:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH3:35])=[CH:17][CH:16]=2)=O)[CH:6]=[CH:7][CH:8]=1.[CH3:36][C:37]1[S:41][CH:40]=[N:39][CH:38]=1.[CH3:42][CH2:43][O:44]CC>C1(C)C=CC=CC=1>[Br-:1].[C:43]([N:12]([CH2:13][CH2:14][C:15]1[CH:16]=[CH:17][C:18]([O:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH3:35])=[CH:19][CH:20]=1)[C:10]1[CH:9]=[C:5]([CH2:4][N+:39]2[CH:38]=[C:37]([CH3:36])[S:41][CH:40]=2)[CH:6]=[CH:7][CH:8]=1)(=[O:44])[CH3:42]