反应详情

To a solution of 15.5 g of m-aminobenzyl alcohol and 36.21 g of pyridine in 250 ml of tetrahydrofuran, cooled to 0° C. is added over 40 minutes a solution of 42 g of p-tetradecyloxyphenylacetyl chloride in 250 ml of tetrahydrofuran. The mixture is stirred overnight at room temperature and the solvent is evaporated. The residue is partitioned between water and chloroform with some heating to afford a complete solution. The hot chloroform solution is washed with warm water and warm dilute hydrochloric acid. The organic layer is dried and evaporated to a residue which is crystallized from carbon tetrachloride to give 40 g of the desired product as a white solid.

1. customthe solvent is evaporated
2. customThe residue is partitioned between water and chloroform with some heating
3. customto afford a complete solution
4. washThe hot chloroform solution is washed with warm water
5. temperaturewarm dilute hydrochloric acid
6. customThe organic layer is dried
7. customevaporated to a residue which
8. customis crystallized from carbon tetrachloride