HCID 67283741, compound → HCID 178421249, compound

HRID 1647633Notes

Reaction equation

HRID 1647633 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][O:5][C@H:6]1[CH2:23][CH2:22][C@@:21]2([CH3:24])[C@H:8]([CH2:9][CH2:10][C@@H:11]3[C@@H:20]2[CH2:19][CH2:18][C@@:16]2([CH3:17])[C@:12]3([OH:30])[CH2:13][CH2:14][C@@H:15]2[C:25]2[CH:29]=[CH:28][O:27][CH:26]=2)[CH2:7]1.[N+:31]([O-:34])([O-])=[O:32].CC1([C:42]([NH2:44])=[NH2+:43])C=C(C)N=N1>C(O)C>[N+:31]([O:30][C@@:12]12[C@H:11]3[C@@H:20]([C@:21]4([CH3:24])[C@H:8]([CH2:9][CH2:10]3)[CH2:7][C@@H:6]([O:5][CH2:4][CH2:3][CH2:2][NH:1][C:42]([NH2:44])=[NH:43])[CH2:23][CH2:22]4)[CH2:19][CH2:18][C@:16]1([CH3:17])[C@@H:15]([C:25]1[CH:29]=[CH:28][O:27][CH:26]=1)[CH2:14][CH2:13]2)([O-:34])=[O:32]

Participants

4

Reactant 2

HCID 67283741HCID 67283741, compoundHCID 70046795HCID 70046795, compound

Product 1

HCID 178421249HCID 178421249, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 0.10 g of 3β-(3-aminopropoxy)-17β-(3-furyl)-5β-androstan-14β-ol (I-ab) in 7 ml of absolute ethanol 0.060 g of 3,5-dimethyl-1-pyrazolylformamidinium nitrate were added and the mixture was kept at reflux temperature for 24 hrs; the ethanol was concentrated under reduced pressure and 0.090 g of the title compound (I-am) crystallized as a white solid.

Workup

  1. temperatureat reflux temperature for 24 hrs
  2. concentrationthe ethanol was concentrated under reduced pressure and 0.090 g of the title compound (I-am)
  3. customcrystallized as a white solid

Sources & evidence

ORD record
ord-762fdce41212401ca2f6610e38f30372
Source dataset
uspto-grants-1995_07
Patent number
US05432169

Reaction notes

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