Methylamine → HCID 70043517, compound

HRID 1647634Notes

Reaction equation

HRID 1647634 reaction equation
[CH3:1][NH2:2].S(O[CH2:14][CH2:15][O:16][C@H:17]1[CH2:34][CH2:33][C@@:32]2([CH3:35])[C@H:19]([CH2:20][CH2:21][C@@H:22]3[C@@H:31]2[CH2:30][CH2:29][C@@:27]2([CH3:28])[C@:23]3([OH:41])[CH2:24][CH2:25][C@@H:26]2[C:36]2[CH:40]=[CH:39][O:38][CH:37]=2)[CH2:18]1)(C1C=CC(C)=CC=1)(=O)=O>CO>[CH3:1][NH:2][CH2:14][CH2:15][O:16][C@H:17]1[CH2:34][CH2:33][C@@:32]2([CH3:35])[C@H:19]([CH2:20][CH2:21][C@@H:22]3[C@@H:31]2[CH2:30][CH2:29][C@@:27]2([CH3:28])[C@:23]3([OH:41])[CH2:24][CH2:25][C@@H:26]2[C:36]2[CH:40]=[CH:39][O:38][CH:37]=2)[CH2:18]1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 86748784HCID 86748784, compound

Product 1

HCID 70043517HCID 70043517, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To 7 ml of a solution of methylamine 3.2 M in methanol, 0.090 g of 3β-(2-tosyloxyethoxy)-17β-(3-furyl)-5β-androstan-14β-ol, prepared as an intermediate in Ex.7, were added. The solution was kept at reflux under nitrogen for 11 hrs, then was evaporated. The resulting solid was washed with n-hexane to give 0.045 g of the title compound (I-an) as a light yellow pasty solid.

Workup

  1. additionwere added
  2. temperatureat reflux under nitrogen for 11 hrs
  3. customwas evaporated
  4. washThe resulting solid was washed with n-hexane

Sources & evidence

ORD record
ord-dbf5b7e0179147249637fc1854d8ad09
Source dataset
uspto-grants-1995_07
Patent number
US05432169

Reaction notes

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