Ammonia → 2-Sulfamoylphenyl methanesulfonate

HRID 1647661Notes

Reaction equation

HRID 1647661 reaction equation
[NH3:1].[CH3:2][S:3]([O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[S:13](Cl)(=[O:15])=[O:14])(=[O:5])=[O:4]>O1CCCC1>[CH3:2][S:3]([O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[S:13]([NH2:1])(=[O:15])=[O:14])(=[O:5])=[O:4]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 19920903HCID 19920903, compound

Product 1

HCID 137693272-Sulfamoylphenyl methanesulfonate

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Ammonia was passed at -30° C. into a solution of 130.3 g of 2-chlorosulfonylphenyl methanesulfonate in 1 l of tetrahydrofuran, and the conversion was checked by thin-layer chromatography. After the reaction was complete, the tetrahydrofuran was distilled off under reduced pressure from a water pump and the residue was triturated with water and diethyl ether. This gave 110.2 g (91%) of the title compound of melting point 131°-132° C.

Workup

  1. distillationthe tetrahydrofuran was distilled off under reduced pressure from a water pump
  2. customthe residue was triturated with water and diethyl ether

Sources & evidence

ORD record
ord-26b766f1fdb1480785bcffe0b69ad96b
Source dataset
uspto-grants-1995_07
Patent number
US05434124

Reaction notes

Loading…