反应详情

293.1 g (1.692 mol) of a 30% strength sodium methylate solution were added to a solution of 434 g (1.692 mol) of 2,6-dichloro-4-trichloromethylpyrimidine in 1 l of 1,2-dichloroethane in the course of 11/2 hours at from 0° to 5° C. while stirring. Stirring was continued for 1 hour at from 0° to 5° C. and for 12 hours at 25° C. The reaction mixture was extracted 4 times with water and 3 times with saturated sodium chloride solution. Drying over magnesium sulfate and evaporating down gave 423 g (95% of theory) of the title compound as a virtually colorless oil.

1. stirringStirring
2. extractionThe reaction mixture was extracted 4 times with water and 3 times with saturated sodium chloride solution
3. dry with materialDrying over magnesium sulfate
4. customevaporating down gave 423 g (95% of theory) of the title compound as a virtually colorless oil