反应详情

温度

25 °C

2.7 g (0.015 mol) of 30% strength sodium methylate were added to 2.95 g (0.015 mol) of 2-amino-4-fluoro-6-trifluoromethoxypyrimidine in 50 ml of methanol in the course of 15 minutes at from -5° to 0° C. while stirring. The reaction mixture was stirred for 1 hour at 0° C., warmed up to 25° C. and then evaporated down under reduced pressure, and the residue was stirred with water and extracted twice with methylene chloride. Drying and evaporating down under reduced pressure gave 3.1 g (98% of theory) of the title compound of nD25 =1.4770.

1. stirringThe reaction mixture was stirred for 1 hour at 0° C.
2. customevaporated down under reduced pressure
3. stirringthe residue was stirred with water
4. extractionextracted twice with methylene chloride
5. customDrying
6. customevaporating down under reduced pressure