Sodium Methoxide → 4-Methoxy-6-(trifluoromethoxy)pyrimidin-2-amine

Participants

Reaction Conditions

Reaction Steps

2.7 g (0.015 mol) of 30% strength sodium methylate were added to 2.95 g (0.015 mol) of 2-amino-4-fluoro-6-trifluoromethoxypyrimidine in 50 ml of methanol in the course of 15 minutes at from -5° to 0° C. while stirring. The reaction mixture was stirred for 1 hour at 0° C., warmed up to 25° C. and then evaporated down under reduced pressure, and the residue was stirred with water and extracted twice with methylene chloride. Drying and evaporating down under reduced pressure gave 3.1 g (98% of theory) of the title compound of nD25 =1.4770.

Provenance & Evidence