Chlorosuccinimide → HCID 178508980, compound

Temperature

90 °C

To 1.87 g. (10 mM) of 2-amino-6-phenyl-4-pyrimidinol is added 50 ml. of glacial acetic acid and 1.46 g. (11 mM) of N-chlorosuccinimide. The mixture is heated with magnetic stirring under nitrogen at 90° C. for 2 hours (solution was complete in less than 20 minutes). The heat is removed and the amber solution is allowed to cool to room temperature. The solution is evaporated to a volume of 10 ml. under vacuum, cooled to 20° C. and filtered. The resulting solids are washed successively with CH3COOH (5 ml.), water (50 ml.), acetone (100 ml.) and diethyl ether (100 ml.). The solids are dried at 60° C. in a vacuum even to yield 1.40 g. (63%) of title compound. The solids can be recrystallized from ethanol:DMF by adding DMF to a hot, ethanol slurry of the pyrimidine until solution is complete. Cooling the solution at 5° C. for 18 hours filtering and drying gives analytically pure 2-amine-5-chloro-6-phenyl-4-pyrimidinol.

1. temperatureThe mixture is heated
2. customThe heat is removed
3. temperatureto cool to room temperature
4. customThe solution is evaporated to a volume of 10 ml
5. temperatureunder vacuum, cooled to 20° C.
6. filtrationfiltered
7. washThe resulting solids are washed successively with CH3COOH (5 ml.), water (50 ml.), acetone (100 ml.) and diethyl ether (100 ml.)
8. customThe solids are dried at 60° C. in a vacuum even
9. customto yield 1.40 g

ORD record

ord-03edc66e01684f768872c6e512d1e3fb

Source dataset

uspto-grants-1995_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05434157