Chloroacetaldehyde → Imidazo[1,2-a]pyridine-8-carboxylic acid hydrochloride

HRID 1647718Notes

Reaction equation

HRID 1647718 reaction equation
[NH2:1][C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[Cl:11][CH2:12][CH:13]=O>>[ClH:11].[N:1]1[CH:12]=[CH:13][N:10]2[CH:9]=[CH:8][CH:7]=[C:3]([C:4]([OH:6])=[O:5])[C:2]=12

Participants

3

Reactant 2

HCID 33ChloroacetaldehydeHCID 729302-Aminonicotinic acid

Product 1

HCID 11715356Imidazo[1,2-a]pyridine-8-carboxylic acid hydrochlorideYield 88%

Procedure

Using 2-aminonicotinic acid (14.1 g, 0.102 mol) and chloroacetaldehyde [45% aqueous solution (8.6 g, 0.11 mol)], the same procedure as described above in example C was used. After workup 17.5 g (88%) of the title compound, m.p. 299°-300° C. (decomp), was isolated.

Sources & evidence

ORD record
ord-1f80b50eab3c45f4860afde8e98ccad0
Source dataset
uspto-grants-1995_07
Patent number
US05434161

Reaction notes

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