反应详情

A suspension of 100g (463 mmol, 1.0 equiv.) of 4-nitrobenzyl bromide and 64.2 g (509 mmol, 1.1 equiv.) of sodium sulfite in 500 mL of methanol and 500 mL of water was heated to reflux. The progress of the reaction was monitored by TLC. When the bromide was consumed, the reaction mixture was allowed to cool to room temperature. The product precipitated and was collected by filtration. It was thoroughly dried for sixteen hours at 65° C. at 0.05 mm Hg to give 100 g (90%) of sodium 4-nitrobenzyl sulfonate.

1. temperaturewas heated to reflux
2. customWhen the bromide was consumed
3. customThe product precipitated
4. filtrationwas collected by filtration
5. customIt was thoroughly dried for sixteen hours at 65° C. at 0.05 mm Hg