反应详情

A solution of methyl 4-(3-methoxy-4-pyridinyl)-1-piperazinecarboxylate (1.2 g, 4.7 mmol) in 50 mL of EtOH containing 1 mL of 85% hydrazine hydrate and potassium hydroxide (12 g, 210 mol) was heated to reflux for 12 h. The reaction mixture was cooled, concentrated in vacuo and the residue dissolved in EtOAc. The organic extracts were dried (brine, MgSO4), filtered and concentrated in vacuo. Silica gel chromatography (3:1:0.01 CH2Cl2 -MeOH-Et3N) of the residue gave the desired compound (0.42 g, 46%).

1. temperatureto reflux for 12 h
2. temperatureThe reaction mixture was cooled
3. concentrationconcentrated in vacuo
4. dissolutionthe residue dissolved in EtOAc
5. dry with materialThe organic extracts were dried (brine, MgSO4)
6. filtrationfiltered
7. concentrationconcentrated in vacuo