Pyrrolidine → HCID 67621128, compound

HRID 1647841Notes

Reaction equation

HRID 1647841 reaction equation
[O:1]1[CH2:5][CH2:4][CH:3]([CH2:6][NH:7][C:8](SC)=[CH:9][N+:10]([O-:12])=[O:11])[CH2:2]1.[NH:15]1[CH2:19][CH2:18][CH2:17][CH2:16]1>C(#N)C>[O:1]1[CH2:5][CH2:4][CH:3]([CH2:6][NH:7][C:8]([N:15]2[CH2:19][CH2:18][CH2:17][CH2:16]2)=[CH:9][N+:10]([O-:12])=[O:11])[CH2:2]1

Participants

4

Reactant 2

HCID 31268PyrrolidineHCID 67619523HCID 67619523, compound

Product 1

HCID 67621128HCID 67621128, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A mixture comprising 1.2 g of 1-[{(tetrahydro-3-furanyl)methyl}amino]-1-methylthio-2-nitroethylene, 1.5 ml of pyrrolidine and 15 ml of acetonitrile was stirred at room temperature for an hour. The reaction mixture was concentrated under a reduced pressure, and purified by silica gel column chromatography (eluent: ethyl acetate/acetone=1/1) to obtain 0.92 g of 1-[{(tetrahydro-3-furanyl)methyl}amino]-1-(1-pyrrolidinyl)-2-nitroethylene.

Workup

  1. concentrationThe reaction mixture was concentrated under a reduced pressure
  2. custompurified by silica gel column chromatography (eluent: ethyl acetate/acetone=1/1)

Sources & evidence

ORD record
ord-3aa215b5e419466f95b5e0afb4400b75
Source dataset
uspto-grants-1995_07
Patent number
US05434181

Reaction notes

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