Potassium Iodide → HCID 139627841, compound

HRID 1647898Notes

Reaction equation

HRID 1647898 reaction equation
[CH2:1]([O:8][C:9]([NH:11][C:12]([C:14]1[CH:19]=[CH:18][C:17]([C:20]2[N:24]([CH2:25][CH2:26][CH2:27][CH2:28][C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[C:23]3[CH:35]=[CH:36][C:37]([C:39]([NH:41][CH2:42][CH2:43][C:44]([OH:46])=[O:45])=[O:40])=[CH:38][C:22]=3[N:21]=2)=[CH:16][CH:15]=1)=[NH:13])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:47]([O:53][CH2:54]Cl)(=[O:52])[C:48]([CH3:51])([CH3:50])[CH3:49].C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>CS(C)=O>[CH2:1]([O:8][C:9]([NH:11][C:12]([C:14]1[CH:19]=[CH:18][C:17]([C:20]2[N:24]([CH2:25][CH2:26][CH2:27][CH2:28][C:29]3[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=3)[C:23]3[CH:35]=[CH:36][C:37]([C:39]([NH:41][CH2:42][CH2:43][C:44]([O:46][CH2:54][O:53][C:47](=[O:52])[C:48]([CH3:51])([CH3:50])[CH3:49])=[O:45])=[O:40])=[CH:38][C:22]=3[N:21]=2)=[CH:16][CH:15]=1)=[NH:13])=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

6

Reactant 4

HCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 87885Chloromethyl pivalateHCID 145821000HCID 145821000, compound

Product 1

HCID 139627841HCID 139627841, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

Prepared by reacting 2-(4-benzyloxycarbonylamidino-phenyl)-5-[(2-carboxy-ethyl)-aminocarbonyl]-1-(4-phenyl-butyl)-benzimidazole with pivaloyloxymethylchloride in dimethylsulphoxide in the presence of potassium carbonate with the addition of potassium iodide at ambient temperature.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-651d69ba78564068b87fa16f985cf375
Source dataset
uspto-grants-1995_07
Patent number
US05434150

Reaction notes

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