O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate → HCID 145821008, compound

HRID 1647900Notes

Reaction equation

HRID 1647900 reaction equation
[CH2:1]([O:8][C:9]([NH:11][C:12]([C:14]1[CH:19]=[CH:18][C:17]([C:20]2[N:24]([CH3:25])[C:23]3[CH:26]=[CH:27][CH:28]=[C:29](C(O)=O)[C:22]=3[N:21]=2)=[CH:16][CH:15]=1)=[NH:13])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:33][C@H:34]([C:46]([O:48][CH2:49][C:50]1[CH:55]=[CH:54][CH:53]=[CH:52][CH:51]=1)=[O:47])[CH2:35][C:36]([O:38][CH2:39][C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1)=[O:37].N1([O:65][C:66](N(C)C)=[N+](C)C)C2C=CC=CC=2N=N1.F[B-](F)(F)F>O1CCCC1>[CH2:1]([O:8][C:9]([NH:11][C:12]([C:14]1[CH:19]=[CH:18][C:17]([C:20]2[N:24]([CH3:25])[C:23]3[CH:26]=[CH:27][C:28]([C:66]([NH:33][CH:34]([C:46]([O:48][CH2:49][C:50]4[CH:51]=[CH:52][CH:53]=[CH:54][CH:55]=4)=[O:47])[CH2:35][C:36]([O:38][CH2:39][C:40]4[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=4)=[O:37])=[O:65])=[CH:29][C:22]=3[N:21]=2)=[CH:16][CH:15]=1)=[NH:13])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 2808532Dibenzyl L-aspartateHCID 145821009HCID 145821009, compound

Product 1

HCID 145821008HCID 145821008, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared from 2-(4-benzyloxycarbonylamidino-phenyl)-1-methyl-benzimidazole-4-carboxylic acid and dibenzyl aspartate with the addition of 2-(1H-benztriazol-1-yl)-1,1,3,3-tetramethyluronium-tetrafluoroborate in tetrahydrofuran.

Sources & evidence

ORD record
ord-a8de483e9fec4089b8946110a5eb16ea
Source dataset
uspto-grants-1995_07
Patent number
US05434150

Reaction notes

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