Trifluoroacetic acid → HCID 19921318, compound

HRID 1647901Notes

Reaction equation

HRID 1647901 reaction equation
C(OC([NH:8][C:9]1([C:12]2[CH:17]=[CH:16][C:15]([C:18]3[N:22]([CH3:23])[C:21]4[CH:24]=[CH:25][C:26]([C:28]([NH:30][CH2:31][CH2:32][C:33]([O:35][CH3:36])=[O:34])=[O:29])=[CH:27][C:20]=4[N:19]=3)=[CH:14][CH:13]=2)[CH2:11][CH2:10]1)=O)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[NH2:8][C:9]1([C:12]2[CH:17]=[CH:16][C:15]([C:18]3[N:22]([CH3:23])[C:21]4[CH:24]=[CH:25][C:26]([C:28]([NH:30][CH2:31][CH2:32][C:33]([O:35][CH3:36])=[O:34])=[O:29])=[CH:27][C:20]=4[N:19]=3)=[CH:14][CH:13]=2)[CH2:10][CH2:11]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 19921482HCID 19921482, compound

Product 1

HCID 19921318HCID 19921318, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Prepared from 2-[4-(1-tert.butyloxycarbonylamino-cyclopropyl)-phenyl]-5-[(2-methoxycarbonyl-ethyl)-aminocarbonyl]-1-methyl-benzimidazole by treating with trifluoroacetic acid in methylene chloride at ambient temperature.

Sources & evidence

ORD record
ord-22b44ac5390c4b12a413e9596fdedffe
Source dataset
uspto-grants-1995_07
Patent number
US05434150

Reaction notes

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