Hydrochloric Acid → HCID 19921419, compound

HRID 1647902Notes

Reaction equation

HRID 1647902 reaction equation
O[N:2]=[C:3]1[C:11]2[C:6](=[CH:7][C:8]([C:12]3[N:16]([CH3:17])[C:15]4[CH:18]=[CH:19][C:20]([C:22]([NH:24][CH2:25][CH2:26][C:27]([O:29][CH3:30])=[O:28])=[O:23])=[CH:21][C:14]=4[N:13]=3)=[CH:9][CH:10]=2)[CH2:5][CH2:4]1.[H][H].Cl>[Pd].CO>[NH2:2][CH:3]1[C:11]2[C:6](=[CH:7][C:8]([C:12]3[N:16]([CH3:17])[C:15]4[CH:18]=[CH:19][C:20]([C:22]([NH:24][CH2:25][CH2:26][C:27]([O:29][CH3:30])=[O:28])=[O:23])=[CH:21][C:14]=4[N:13]=3)=[CH:9][CH:10]=2)[CH2:5][CH2:4]1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 136401242HCID 136401242, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 19921419HCID 19921419, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Prepared from 2-(1-hydroxyimino-5-indanyl)-5-[(2-methoxycarbonyl-ethyl)-aminocarbonyl]-1-methyl-benzimidazole by reduction with 5 bars of hydrogen in a 50:1 mixture of methanol and methanolic hydrochloric acid at ambient temperature in the presence of 10% palladium/charcoal.

Sources & evidence

ORD record
ord-77b9d62b315d46c29a406ef912ca2aab
Source dataset
uspto-grants-1995_07
Patent number
US05434150

Reaction notes

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