反应详情

To a solution of 31.4 g (0.18 mol) of 4-phenylcyclohexanone in 500 ml of absolute methanol, which is cooled to -10° C., are added 6.8 g (0.18 mol) of sodium borohydride in batches with stirring. The reaction mixture is allowed to react for 0.5 hours at -10° C. and for 3 hours at ambient temperature and then evaporated down in vacuo. The residue remaining is mixed with water and acidified with 2N hydrochloric acid. The suspension formed is stirred for 1 hour and the crystalline product is suction filtered, dried and recrystallised from diisopropylether. 21 g (66% of theory) of 4-phenylcyclohexanol are obtained, melting point: 112°-114° C.

1. customto react for 0.5 hours at -10° C. and for 3 hours at ambient temperature
2. customevaporated down in vacuo
3. additionThe residue remaining is mixed with water
4. customThe suspension formed
5. stirringis stirred for 1 hour
6. filtrationfiltered
7. customdried
8. customrecrystallised from diisopropylether