反应详情

A quantity of 0.38 g (8.0 mmole) of 50% sodium hydride oil dispersion was added slowly during 15 minutes to 20 ml of ethyl sulfoxide at room temperature. After completion of addition, the reaction mixture was heated at 45° for 30 minutes. It was cooled to 15° and a solution of 2.3 g (8.0 mmole) of 9-(4-pyridinylmethyl)thioxanthene in 10 ml of dimethylsulfoxide was added dropwise during 15 minutes at room temperature. After completion of addition, the reaction mixture was stirred 30 minutes at room temperature. Then a solution of 4-picolylchloride (8.75 mmole) in 5 ml of dimethylsulfoxide was added dropwise during 30 minutes at ambient temperature. The reaction was then heated at 40° for 30 minutes. The reaction was quenched by addition of water (50 ml). Trituration of the precipitated oil yielded a crystalline solid, which was filtered off, washed with water and dried. The tan solid was dissolved in benzene and decolorized by stirring with 1 g of Magnesol® for 30 minutes. Filtration and evaporation yielded a colorless product (2.0 g) which was recrystallized from ethylacetate, m.p., 201.4°-203.4°.

1. additionAfter completion of addition
2. temperaturethe reaction mixture was heated at 45° for 30 minutes
3. temperatureIt was cooled to 15°
4. additionAfter completion of addition
5. temperatureThe reaction was then heated at 40° for 30 minutes
6. customThe reaction was quenched by addition of water (50 ml)
7. customTrituration of the precipitated oil yielded a crystalline solid, which
8. filtrationwas filtered off
9. washwashed with water
10. customdried
11. dissolutionThe tan solid was dissolved in benzene
12. stirringby stirring with 1 g of Magnesol® for 30 minutes
13. filtrationFiltration and evaporation