反应详情

1-Methyl-1-(3,5-dichlorophenyl)ethylamine (7.5 g) was added slowly to formalin (aqueous 37% HCHO solution) (4.6 g) at room temperature. This was allowed to react as it was for 7 hours. A saturated aqueous sodium hydrogen carbonate solution was added to the reaction mixture, which was then extracted with ether. After it was washed with saturated saline, the organic layer was dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure to obtain the captioned compound (8.6 g) as white crystals.

1. customto react as it
2. extractionwas then extracted with ether
3. washAfter it was washed with saturated saline
4. dry with materialthe organic layer was dried over anhydrous sodium sulfate
5. distillationThe solvent was distilled off under reduced pressure