反应详情

To a solution of 5-chloroanthranilamide (3.4 g)in tetrahydrofuran (50 mL) was added phosgene (16 mL, 1.93M solution in toluene) via an addition funnel. The reaction mixture was stirred at room temperature for 4 hours and then heated to reflux for another two hours. The reaction mixture was concentrated to a total volume about 10 mL. After cooling, the title compound (3.72 g) having the following physical data, was collected by filtration and dried in vacuum.

1. temperatureheated
2. temperatureto reflux for another two hours
3. concentrationThe reaction mixture was concentrated to a total volume about 10 mL
4. temperatureAfter cooling
5. filtrationwas collected by filtration
6. customdried in vacuum