Tetrabutylammonium Fluoride → HCID 9860877, compound

HRID 1648221Notes

Reaction equation

HRID 1648221 reaction equation
[N:1]1([C:6]2[N:15]=[C:14]([NH:16][CH2:17][CH2:18][O:19][CH3:20])[C:13]3[C:8](=[CH:9][CH:10]=[C:11]([C:21]#[C:22][Si](CC)(CC)CC)[CH:12]=3)[N:7]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.[F-].C([N+](CCCC)(CCCC)CCCC)CCC>C1COCC1>[C:21]([C:11]1[CH:12]=[C:13]2[C:8](=[CH:9][CH:10]=1)[N:7]=[C:6]([N:1]1[CH:5]=[CH:4][N:3]=[CH:2]1)[N:15]=[C:14]2[NH:16][CH2:17][CH2:18][O:19][CH3:20])#[CH:22]

Participants

4

Reactant 2

HCID 2724141Tetrabutylammonium FluorideHCID 19392198HCID 19392198, compound

Product 1

HCID 9860877HCID 9860877, compoundYield 85.4%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To 1.35 g of the compound prepared in example 17 in 20 mL of THF was added 3.3 mL of tetrabutylammonium fluoride (1M in THF). Stirred at room temperature for 1.5 hrs. The excess THF was removed under reduced pressure and the residue taken up in chloroform and water. The insoluble precipitate was collected by filtration. Yielded 0.83 g of the title compound.

Workup

  1. customThe excess THF was removed under reduced pressure
  2. filtrationThe insoluble precipitate was collected by filtration

Sources & evidence

ORD record
ord-80e016eb272f46ef8080ae5879fed845
Source dataset
uspto-grants-1995_07
Patent number
US05436233

Reaction notes

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