Acetonitrile → 2-Methylquinazoline

HRID 1648248Notes

Reaction equation

[NH2:1][C:2]1[CH:15]=[CH:14][CH:13]=[CH:12][C:3]=1[C:4](C1C=CC=CC=1)=O.[C:16](#[N:18])[CH3:17]>>[CH3:17][C:16]1[N:18]=[CH:4][C:3]2[C:2](=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:1]=1

Participants

Reactant 2

HCID 6342Acetonitrile

HCID 760802-Aminobenzophenone

Product 1

HCID 5889872-Methylquinazoline

Procedure

In this method, 2-aminobenzophenone derivative (IV) is reacted with acetonitrile to yield 2-methylquinazoline derivative (IX), which is then brominated to 2-bromomethylquinazoline derivative (II-4). The reaction of compound (IV) and acetonitrile is carried out in the same manner as method D. Bromination of compound (IX) is carried out in the same manner as the bromination of compound (VII) by method C.

Sources & evidence

ORD record: ord-24ef11ca3139447cbf6d3fe0c9ffbb64
Source dataset: uspto-grants-1995_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05436247

Reaction notes

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