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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1648248Generated: October 26, 2026

Acetonitrile → 2-Methylquinazoline

https://huagongshe.com/reaction/1648248

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAcetonitrileHCID 6342—
Reactant2-AminobenzophenoneHCID 76080—
Product2-MethylquinazolineHCID 588987—

Reaction Steps

In this method, 2-aminobenzophenone derivative (IV) is reacted with acetonitrile to yield 2-methylquinazoline derivative (IX), which is then brominated to 2-bromomethylquinazoline derivative (II-4). The reaction of compound (IV) and acetonitrile is carried out in the same manner as method D. Bromination of compound (IX) is carried out in the same manner as the bromination of compound (VII) by method C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05436247
Source datasetuspto-grants-1995_07
ORD IDord-24ef11ca3139447cbf6d3fe0c9ffbb64
Source noteuspto-grants-1995_07