Isopropyl chloroformate → HCID 10078554, compound

Participants

Reaction Steps

The titled compound was prepared from 2-[2-bromo-5-(valerylamino)phenyl]-2,4-dihydro-5-ethyl-4-[(3-fluoro-2'-sulfamoyl -biphenyl-4-yl)methyl]-3H-1,2,4-triazol-3-one (from Example 1, Step J) as described in Example 1, Step K, except that isopropyl chloroformate was used in place of di-t-butyl dicarbonate, and THF was used as the solvent. After chromatographic purification, the titled compound was obtained in 15% yield; mass spectrum (FAB) m/e 716,718 (M+1)+.

Provenance & Evidence