Isopropyl chloroformate → HCID 10078554, compound

HRID 1648348Notes

Reaction equation

HRID 1648348 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:14])[CH2:10][CH2:11][CH2:12][CH3:13])=[CH:4][C:3]=1[N:15]1[C:19](=[O:20])[N:18]([CH2:21][C:22]2[CH:27]=[CH:26][C:25]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=3[S:34](=[O:37])(=[O:36])[NH2:35])=[CH:24][C:23]=2[F:38])[C:17]([CH2:39][CH3:40])=[N:16]1.Cl[C:42]([O:44][CH:45]([CH3:47])[CH3:46])=[O:43]>C1COCC1>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:14])[CH2:10][CH2:11][CH2:12][CH3:13])=[CH:4][C:3]=1[N:15]1[C:19](=[O:20])[N:18]([CH2:21][C:22]2[CH:27]=[CH:26][C:25]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=3[S:34](=[O:37])(=[O:36])[NH:35][C:42]([O:44][CH:45]([CH3:47])[CH3:46])=[O:43])=[CH:24][C:23]=2[F:38])[C:17]([CH2:39][CH3:40])=[N:16]1

Participants

4

Reactant 2

HCID 7917Isopropyl chloroformateHCID 10009184HCID 10009184, compound

Product 1

HCID 10078554HCID 10078554, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The titled compound was prepared from 2-[2-bromo-5-(valerylamino)phenyl]-2,4-dihydro-5-ethyl-4-[(3-fluoro-2'-sulfamoyl -biphenyl-4-yl)methyl]-3H-1,2,4-triazol-3-one (from Example 1, Step J) as described in Example 1, Step K, except that isopropyl chloroformate was used in place of di-t-butyl dicarbonate, and THF was used as the solvent. After chromatographic purification, the titled compound was obtained in 15% yield; mass spectrum (FAB) m/e 716,718 (M+1)+.

Workup

  1. customAfter chromatographic purification

Sources & evidence

ORD record
ord-96401d621bb84f3a99e9801c75c9e063
Source dataset
uspto-grants-1995_07
Patent number
US05436259

Reaction notes

Loading…