Ethyl formate → HCID 19919895, compound

HRID 1648352Notes

Reaction equation

HRID 1648352 reaction equation
[NH2:1][C:2]1([CH2:12][OH:13])[CH2:11][CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3]1.[CH:14](OCC)=[O:15]>ClCCl>[CH:14]([NH:1][C:2]1([CH2:12][OH:13])[CH2:11][CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3]1)=[O:15]

Participants

4

Reactant 2

HCID 8025Ethyl formateHCID 9989786HCID 9989786, compound

Product 1

HCID 19919895HCID 19919895, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution containing 5.6 mmol of the compound obtained in Stage D of Example 35 in 5 ml of ethyl formate is left overnight at room temperature. The solution is then diluted with 25 ml of dichloromethane, the solid is filtered off and the tiltrate is evaporated. The residue is then purified by chromatography on a silica column using a dichloromethane/ethanol (95:5) mixture as eluent.

Workup

  1. filtrationthe solid is filtered off
  2. customthe tiltrate is evaporated
  3. customThe residue is then purified by chromatography on a silica column

Sources & evidence

ORD record
ord-c39f5c8748194514a2028064c59b2327
Source dataset
uspto-grants-1995_07
Patent number
US05436261

Reaction notes

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