1-(1H-indol-3-yl)-2-methylpropan-2-amine → HCID 19919968, compound

HRID 1648413Notes

Reaction equation

HRID 1648413 reaction equation
CS(O[CH2:6][CH2:7][O:8][C:9]1[CH:14]=[C:13]([O:15]C(C2C=CC=CC=2)C2C=CC=CC=2)[CH:12]=[CH:11][C:10]=1[O:29][CH2:30][CH:31]([CH3:33])[CH3:32])(=O)=O.[Cl:34][C:35]1[CH:36]=[C:37]2[C:41](=[CH:42][CH:43]=1)[NH:40][CH:39]=[C:38]2[CH2:44][C:45]([NH2:48])([CH3:47])[CH3:46].N1C2C(=CC=CC=2)C(CC(N)(C)C)=C1>>[ClH:34].[NH:40]1[C:41]2[C:37](=[CH:36][CH:35]=[CH:43][CH:42]=2)[C:38]([CH2:44][C:45]([NH:48][CH2:6][CH2:7][O:8][C:9]2[CH:14]=[C:13]([OH:15])[CH:12]=[CH:11][C:10]=2[O:29][CH2:30][CH:31]([CH3:32])[CH3:33])([CH3:46])[CH3:47])=[CH:39]1

Participants

4

Reactant 3

HCID 93531-(1H-indol-3-yl)-2-methylpropan-2-amineHCID 132605-Chloro-alpha,alpha-dimethyl-1H-indole-3-ethanamineHCID 19919937HCID 19919937, compound

Product 1

HCID 19919968HCID 19919968, compound

Procedure

Proceeding as in Example 3, but replacing 2-[2-(cyclopropylmethyloxy)phenoxy]ethyl methanesulfonate with 2- [5-diphenylmethyloxy-2-(2-methylprop-1-yloxy)phenoxy]ethyl methanesulfonate and [2-(5-chloro-1H-indol-3-yl)-1,1-dimethylethyl]amine with [2-(1H-indol-3-yl)-1,1-dimethylethyl]amine and then removing the protective group, gave [2-(1H-indol-3-yl)-1,1-dimethylethyl]{2-[5-hydroxy-2-(2-methylprop-1-yloxy)phenoxy]ethyl}amine hydrochloride.

Workup

  1. customremoving the protective group

Sources & evidence

ORD record
ord-abc263c9c4e0490c9fe2ae2101905d79
Source dataset
uspto-grants-1995_07
Patent number
US05436264

Reaction notes

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